Stacks
A stack is a combination of compounds commonly used together in the research community. PeptideClear covers what each stack contains — not how to use them.
KLOW
GHK-Cu · KPV · BPC-157 · TB-500
A branded four-compound combination representing the most comprehensive recovery and anti-inflammatory stack commonly referenced in the biohacking community. KLOW builds directly on the GLOW Stack by adding KPV, an alpha-MSH derived tripeptide that inhibits NF-κB signaling and suppresses pro-inflammatory cytokines, creating four-axis coverage: localized angiogenesis (BPC-157), systemic cell migration (TB-500), extracellular matrix remodeling (GHK-Cu), and intracellular inflammation regulation (KPV). The addition of KPV is intended to remove the inflammatory microenvironment that can impair the tissue repair activity of the other three compounds. PeptideClear covers each component individually, click any compound below to read its full evidence profile.
Commonly cited for: Tissue repair · Systemic inflammation reduction · Skin quality · Gut healing
GLOW
GHK-Cu · BPC-157 · TB-500
A branded three-compound combination popularized in biohacking and beauty communities, particularly on TikTok and Reddit. The GLOW Stack is essentially the Wolverine Stack with GHK-Cu added, extending the focus from tissue repair into skin quality, collagen synthesis, and anti-aging outcomes. Each component targets a different axis of healing: BPC-157 drives localized angiogenesis, TB-500 enables systemic cell migration, and GHK-Cu addresses extracellular matrix remodeling. PeptideClear covers each component individually, click any compound below to read its full evidence profile.
Commonly cited for: Tissue repair · Skin quality · Collagen synthesis · Anti-aging
Wolverine
BPC-157 · TB-500
The foundational recovery stack in the biohacking and peptide research community, named after the Marvel character's regenerative abilities. The Wolverine Stack combines two compounds that target complementary axes of tissue repair. BPC-157 drives localized angiogenesis while TB-500 enables systemic cell migration, together covering both vascular and cellular dimensions of wound healing. It is the base from which the GLOW and KLOW stacks are built. PeptideClear covers each component individually, click any compound below to read its full evidence profile.
Commonly cited for: Injury recovery · Tendon and joint repair · Gut healing · Tissue repair
CJC-1295 · Ipamorelin
CJC-1295 · Ipamorelin
This combination utilizes two distinct secretagogues to influence the natural pulsatile release of endogenous growth hormone. CJC-1295 is a synthetic GHRH (Growth Hormone Releasing Hormone) analog that increases plasma GH levels by binding to specific pituitary receptors. Ipamorelin is a selective ghrelin receptor agonist that triggers a GH pulse while maintaining a high degree of selectivity, typically avoiding the stimulation of ACTH, cortisol, or prolactin. By targeting two separate pathways, the GHRH receptor and the Ghrelin receptor, the combination is cited in research for producing a synergistic effect on GH secretion that exceeds the capacity of either peptide used in isolation. PeptideClear covers each component individually, click any compound below to read its full evidence profile.
Commonly cited for: Endogenous GH secretion · Body composition · Sleep quality · Tissue repair
Semax · Selank
Semax · Selank
A cognitive and anxiolytic stack gaining traction in nootropic and biohacking communities, particularly among those seeking mental clarity without stimulant side effects. Semax is a synthetic analog of ACTH known for its neuroprotective and focus-enhancing properties, while Selank is a synthetic analog of tuftsin that acts on the GABAergic system to reduce anxiety and stabilize mood. Together they target complementary axes of cognitive performance: Semax drives BDNF upregulation and dopaminergic activity while Selank modulates stress response and promotes calm focus. The combination is popular in Eastern European clinical research, where both compounds originated. PeptideClear covers each component individually, click any compound below to read its full evidence profile.
Commonly cited for: Cognitive clarity · Anxiety reduction · Mood stabilization · Neuroprotection
Argirelox
Argireline · Leuphasyl
A cosmeceutical peptide stack combining two peptides that work on the same pathway to relax the small facial muscles responsible for expression lines. Argireline and Leuphasyl each target a different step in the same process, when paired, the effect is stronger than either compound alone. The combination is how both peptides are most commonly studied in human trials, and it's the format you'll find in most commercial anti-aging serums that use them. PeptideClear covers each component individually; click any compound below to read its full evidence profile.
Commonly cited for: Forehead lines · Crow's feet · Expression wrinkle reduction · Topical anti-aging
We break down the compounds behind these stacks every week
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