TB-500
TB or Wolverine
Recovery & Performance
Animal Only
A synthetic peptide derived from Thymosin Beta-4, a protein naturally present in human cells. Studied in animal models for muscle and tendon repair, wound healing, and cardiac tissue recovery. Widely used alongside BPC-157 as a recovery stack in the biohacking community. No human clinical trials completed to date.
Injectable
Research Compound
What It Is
TB-500 is a synthetic peptide derived from Thymosin Beta-4, a naturally occurring protein found in virtually all human and animal cells. It is one of the most abundant proteins in the body and plays a central role in cell building and repair. TB-500 specifically replicates the active region of Thymosin Beta-4 responsible for most of its regenerative properties.
Mechanism of Action
TB-500 works primarily by up-regulating actin, a protein essential for cell structure, movement, and division. By promoting actin polymerization it accelerates cell migration to injury sites, stimulates new blood vessel formation, and reduces inflammation. It also modulates stem cell differentiation, which may contribute to its reported tissue repair properties across muscle, tendon, ligament, skin, and cardiac tissue.
Use Cases
In animal research TB-500 has been studied for muscle injury recovery, tendon and ligament repair, cardiac tissue healing following heart attack, wound healing, and hair regrowth. It is widely used alongside BPC-157 in the biohacking and athletic performance community as a recovery stack. Some limited human data exists from Thymosin Beta-4 clinical trials, though TB-500 itself has not been studied in human trials.
Known Risks
Human safety data is limited. Considerations include: no established safe human dosing range, unknown long-term effects, theoretical concern around cancer cell migration given its role in promoting cell movement, potential interaction with anticoagulants due to effects on platelet aggregation. Not recommended during pregnancy. As with BPC-157, individuals with a history of cancer should exercise significant caution given the peptide's pro-angiogenic and cell-migration-promoting properties.
Available Forms
Injectable (subcutaneous or intramuscular). No established oral form — TB-500 is a larger peptide and is generally considered to have poor oral bioavailability. Typically sold as a lyophilized powder requiring reconstitution with bacteriostatic water before injection.
Regulatory Status
TB-500 is not FDA approved for human use. Sold as a research compound labeled "not for human consumption." Not currently on any FDA compounding list. Legal to purchase and possess but not to administer as a drug without a prescription.
Sources
https://pubmed.ncbi.nlm.nih.gov/16099219/
https://pubmed.ncbi.nlm.nih.gov/15565145/
https://pubmed.ncbi.nlm.nih.gov/20536453/
Similar Compounds
BPC-157, Ipamorelin, GHK-Cu
