Hormones & Neuromodulators
CAS
374675-21-5
Molecular Weight
1302
Da
A decapeptide that acts one step upstream of GnRH to stimulate the reproductive hormone axis. Studied primarily in fertility medicine and reproductive endocrinology at academic centers including Imperial College London, with its strongest evidence in IVF oocyte-maturation triggering.
Injectable · IV
Intranasal Suitable
Uncertain
Research Compound
Community signal is active but considerably more skeptical and self-aware than most hormone-axis compounds, concentrated in TRT, post-cycle-therapy, and male-fertility circles. It is frequently discussed as a "natural PCT" or "HPTA restart" and as an alternative entry point to the same axis HCG and Gonadorelin target. The most important signal-versus-evidence gap, which the more informed members of the community actively call out, is the half-life problem: the human research shows Kisspeptin-10 produces a transient LH pulse lasting hours, so reports of single injections producing lasting libido or testosterone changes are widely (and correctly) attributed to placebo or unrelated hormonal recovery rather than the peptide's actual pharmacology. Sustained effect would require frequent pulsatile dosing, which most self-directed protocols do not replicate. Sourcing and dosing-accuracy concerns are common, and experienced users tend to emphasize that without before-and-after hormone panels, subjective reports carry little signal here.
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The shortest biologically active fragment of the kisspeptin family, Kisspeptin-10 activates the KISS1R receptor on GnRH-producing neurons in the hypothalamus, triggering downstream release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Human research began in the mid-2000s, building on the discovery that inactivating mutations in the kisspeptin pathway cause pubertal failure and activating mutations cause precocious puberty.
Acts on GnRH neurons via the KISS1R receptor, one step upstream of GnRH itself, rather than mimicking GnRH directly (the mechanism used by Gonadorelin). In healthy men, a single subcutaneous dose produces a measurable LH pulse within roughly 90 minutes, peaking around two to three hours and then subsiding. This upstream position, and the transient nature of the response, are the defining features of the compound.
Strongest evidence is in IVF oocyte-maturation triggering as a physiological alternative to hCG, where it shows a more favorable profile against ovarian hyperstimulation syndrome. Also studied for reproductive hormone stimulation, hypoactive sexual desire disorder (HSDD), and fertility restoration. The community-discussed use as a TRT-adjunct or PCT agent for testicular-function preservation has comparatively thin direct evidence relative to the reproductive-medicine literature.
Excellent safety profile across Phase 1–2 trials at Imperial College London and other centers, with no serious adverse events reported in healthy volunteers or reproductive-disorder patients. The most common effects, flushing and a sensation of warmth, are mechanism-related and short-lived. A 95-participant study confirmed it does not cause anxiety or negative psychological effects. Short plasma half-life necessitates frequent dosing for any sustained effect. As an unapproved research compound, contamination and mislabeling from unregulated suppliers are real considerations.
Human trials have predominantly used IV infusion in controlled research settings. Subcutaneous administration is the norm in non-clinical community contexts but has less direct trial support than the IV research base.
Following a negative FDA Advisory Committee vote in late 2024, Kisspeptin-10 occupies an unsettled regulatory position. It is not FDA-approved for any indication and is available primarily through research-chemical channels labeled "not for human consumption." A clear candidate for the Live Regulatory Tracker page.
https://pubmed.ncbi.nlm.nih.gov/21632807/
https://pubmed.ncbi.nlm.nih.gov/36735255/
Gonadorelin, PT-141
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