Kisspeptin-10

Kisspeptin-10

KP-10

KP-10

Hormones & Neuromodulators

CAS

374675-21-5

Molecular Weight

1302

Da

Human RCT

Human RCT

A decapeptide that acts one step upstream of GnRH to stimulate the reproductive hormone axis. Studied primarily in fertility medicine and reproductive endocrinology at academic centers including Imperial College London, with its strongest evidence in IVF oocyte-maturation triggering.

Injectable · IV

Intranasal Suitable

Uncertain

Intranasal Suitable

Uncertain

Intranasal Suitable

Uncertain

Research Compound

Research Quality Score
7 dimensions · 100 points total · Methodology by PeptideClear
47/100
Limited Evidence
Study Design
10/25
Sample Size
4/20
Replication
10/20
Journal Impact Factor
12/15
Funding Independence
7/10
Population Diversity
1/5
Researcher h-Index
3/5
Dimension Breakdown
Study DesignQuality of research methodology — RCT, observational, animal, or in vitro
10/ 25
Sample SizeNumber of participants across studies supporting this compound
4/ 20
ReplicationIndependent reproduction of findings by separate research groups
10/ 20
Journal Impact FactorPrestige of journals where primary studies were published
12/ 15
Funding IndependenceDegree to which research was funded independently of industry
7/ 10
Population DiversityDiversity of study participants across age, sex, and ethnicity
1/ 5
Researcher h-IndexCitation credibility of the primary research team
3/ 5
Scored by PeptideClear editorial team · Based on publicly available literature
StrongModerateLimitedWeak

Community Signal

Community Signal

Community signal is active but considerably more skeptical and self-aware than most hormone-axis compounds, concentrated in TRT, post-cycle-therapy, and male-fertility circles. It is frequently discussed as a "natural PCT" or "HPTA restart" and as an alternative entry point to the same axis HCG and Gonadorelin target. The most important signal-versus-evidence gap, which the more informed members of the community actively call out, is the half-life problem: the human research shows Kisspeptin-10 produces a transient LH pulse lasting hours, so reports of single injections producing lasting libido or testosterone changes are widely (and correctly) attributed to placebo or unrelated hormonal recovery rather than the peptide's actual pharmacology. Sustained effect would require frequent pulsatile dosing, which most self-directed protocols do not replicate. Sourcing and dosing-accuracy concerns are common, and experienced users tend to emphasize that without before-and-after hormone panels, subjective reports carry little signal here.

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What It Is

What It Is

The shortest biologically active fragment of the kisspeptin family, Kisspeptin-10 activates the KISS1R receptor on GnRH-producing neurons in the hypothalamus, triggering downstream release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Human research began in the mid-2000s, building on the discovery that inactivating mutations in the kisspeptin pathway cause pubertal failure and activating mutations cause precocious puberty.

Mechanism of Action

Mechanism of Action

Acts on GnRH neurons via the KISS1R receptor, one step upstream of GnRH itself, rather than mimicking GnRH directly (the mechanism used by Gonadorelin). In healthy men, a single subcutaneous dose produces a measurable LH pulse within roughly 90 minutes, peaking around two to three hours and then subsiding. This upstream position, and the transient nature of the response, are the defining features of the compound.

Use Cases

Use Cases

Strongest evidence is in IVF oocyte-maturation triggering as a physiological alternative to hCG, where it shows a more favorable profile against ovarian hyperstimulation syndrome. Also studied for reproductive hormone stimulation, hypoactive sexual desire disorder (HSDD), and fertility restoration. The community-discussed use as a TRT-adjunct or PCT agent for testicular-function preservation has comparatively thin direct evidence relative to the reproductive-medicine literature.

Known Risks

Known Risks

Excellent safety profile across Phase 1–2 trials at Imperial College London and other centers, with no serious adverse events reported in healthy volunteers or reproductive-disorder patients. The most common effects, flushing and a sensation of warmth, are mechanism-related and short-lived. A 95-participant study confirmed it does not cause anxiety or negative psychological effects. Short plasma half-life necessitates frequent dosing for any sustained effect. As an unapproved research compound, contamination and mislabeling from unregulated suppliers are real considerations.

Available Forms

Available Forms

Human trials have predominantly used IV infusion in controlled research settings. Subcutaneous administration is the norm in non-clinical community contexts but has less direct trial support than the IV research base.

Regulatory Status

Regulatory Status

Following a negative FDA Advisory Committee vote in late 2024, Kisspeptin-10 occupies an unsettled regulatory position. It is not FDA-approved for any indication and is available primarily through research-chemical channels labeled "not for human consumption." A clear candidate for the Live Regulatory Tracker page.

Sources

Sources

https://pubmed.ncbi.nlm.nih.gov/21632807/

https://pubmed.ncbi.nlm.nih.gov/36735255/


Similar Compounds

Similar Compounds

Gonadorelin, PT-141

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