Curious about peptides? Start here.

Plain-English profiles on 37 major peptides. What the science actually shows, who funds the research, and what's FDA approved vs. what isn't. Free, always.

Plain-English profiles on 37 major peptides. What the science actually shows, who funds the research, and what's FDA approved vs. what isn't. Free, always.

Our commitment to transparency

Our commitment to transparency

  • PubMed Cited

    Evidence Graded

    No Sponsorships

    Risks Disclosed

    Zero Bias

    Primary Literature

    Transparent Sourcing

The peptide space is full of bold claims. We show you the evidence behind them.

The peptide space is full of bold claims. We show you the evidence behind them.

Whether you're just starting to explore or ready to go deeper — every profile is built on peer-reviewed research, not sponsorships, not affiliate pressure, not influencer opinion.

Foundational SupplementsHuman RCT
Creatine structure
Creatine
Creatine Monohydrate
93
Creatine
Creatine Monohydrate
Human RCT
The most extensively researched performance supplement in existence with over 500 peer-reviewed studies. Increases muscle phosphocreatine stores to extend high intensity exercise capacity, accelerate strength gains, and support lean muscle development. Emerging evidence supports cognitive and neuroprotective benefits. Exceptionally safe profile validated across decades of research.
StatusOTC Supplement
FormsOral · Powder
View Full Intel →
Peptide-AdjacentAnimal / In Vitro
Turkesterone structure
Turkesterone
Turk
37
Turkesterone
Turk
Animal / In Vitro
A naturally occurring plant-derived ecdysteroid extracted from Ajuga turkestanica, popularized as a natural alternative to anabolic steroids. Does not appear to bind androgen receptors and is not expected to cause hormonal suppression. Human evidence base is currently very limited and does not match the boldness of mainstream fitness claims.
StatusOTC Supplement
FormsOral · Capsule
View Full Intel →
Growth HormoneObservational
Ibutamoren structure
Ibutamoren
MK-677
63
Ibutamoren
MK-677
Observational
An orally active non-peptide compound that mimics ghrelin to stimulate sustained growth hormone and IGF-1 release. The only compound in this catalog that achieves growth hormone secretagogue effects without injection. Has reached Phase II human clinical trials for muscle wasting and hip fracture recovery. Sold as a research compound, not FDA approved.
StatusResearch Compound
FormsOral
View Full Intel →
MetabolicHuman RCT
Retatrutide structure
Retatrutide
Reta or Triple G
59
Retatrutide
Reta or Triple G
Human RCT
The most advanced peptide in active clinical development on PeptideClear. A triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously — producing weight loss results in Phase II trials (~24% body weight) that exceed both semaglutide and tirzepatide. Currently in Phase III trials with Eli Lilly. PeptideClear is actively tracking its path to approval.
StatusEmerging / Clinical Trial
FormsInjectable
View Full Intel →
MetabolicHuman RCT
GLP-1 structure
GLP-1
GLP
94
GLP-1
GLP
Human RCT
A naturally occurring hormone whose synthetic analogs — including semaglutide (Ozempic, Wegovy) and liraglutide — have become among the most prescribed medications in the world. FDA approved with an extensive clinical evidence base. Works by stimulating insulin release, suppressing appetite, and slowing gastric emptying. Requires a prescription through a licensed provider.
StatusPrescription
FormsInjectable · Oral
View Full Intel →
Growth HormoneHuman RCT
Sermorelin structure
Sermorelin
Serm
64
Sermorelin
Serm
Human RCT
A synthetic analog of the body's natural Growth Hormone Releasing Hormone (GHRH), comprising its first 29 amino acids. The only peptide in this catalog with prior FDA approval history, previously prescribed for pediatric growth hormone deficiency. Available through licensed compounding pharmacies by prescription. Stimulates the pituitary to produce growth hormone naturally.
StatusPrescription
FormsInjectable
View Full Intel →
Growth HormoneAnimal Only
Ipamorelin structure
Ipamorelin
IPA
35
Ipamorelin
IPA
Animal Only
A selective synthetic peptide that stimulates growth hormone release from the pituitary gland without significantly affecting cortisol or prolactin. One of the most popular peptides in longevity and performance protocols due to its clean hormonal profile. Has reached human clinical trials. Often combined with CJC-1295 for amplified effect.
StatusResearch Compound
FormsInjectable
View Full Intel →
Recovery & PerformanceAnimal Only
TB-500 structure
TB-500
TB or Wolverine
41
TB-500
TB or Wolverine
Animal Only
A synthetic peptide derived from Thymosin Beta-4, a protein naturally present in human cells. Studied in animal models for muscle and tendon repair, wound healing, and cardiac tissue recovery. Widely used alongside BPC-157 as a recovery stack in the biohacking community. No human clinical trials completed to date. Note: often confused with TB-500 Fragment — CAS 77591-33-4 confirms full Thymosin Beta-4.
StatusResearch Compound
FormsInjectable
View Full Intel →
Longevity & Cellular AgingHuman RCT
Carnosine structure
Carnosine
Car
73
Carnosine
Car
Human RCT
A naturally occurring dipeptide found in high concentrations in muscle and brain tissue, first discovered in 1900. Works through four distinct mechanisms — pH buffering, antioxidant activity, anti-glycation, and heavy metal chelation. Strong human RCT evidence for athletic endurance, skin anti-aging, cognitive protection, and blood sugar regulation. OTC with over 120 years of research history.
StatusOTC Supplement
FormsOral · Capsule
View Full Intel →
Skin & HairHuman RCT
Palmitoyl Tripeptide-1 structure
Palmitoyl Tripeptide-1
Matrixyl
51
Palmitoyl Tripeptide-1
Matrixyl
Human RCT
A synthetic peptide commercially known as Matrixyl, purpose-built for skincare. Works as a matrikine, mimicking a collagen breakdown signal that triggers fibroblasts to produce new collagen, elastin, and hyaluronic acid. One of the most widely used and well-studied peptides in the global skincare industry with strong human evidence for wrinkle reduction and skin firmness. Safe for use during pregnancy.
StatusOTC Supplement
FormsTopical · Serum
View Full Intel →
Skin & HairHuman RCT
GHK-Cu structure
GHK-Cu
Copper
55
GHK-Cu
Copper
Human RCT
A naturally occurring copper-bound tripeptide first isolated from human plasma in 1973, with levels declining significantly with age. Stimulates collagen and elastin synthesis, promotes wound healing, and demonstrates gene expression resetting properties in aging cells. The only peptide in this catalog that spans both mainstream OTC skincare and the gray zone research community.
StatusOTC Supplement
FormsTopical · Serum
View Full Intel →
Skin & HairHuman RCT
Collagen Type III structure
Collagen Type III
Col-III
68
Collagen Type III
Col-III
Human RCT
The second most abundant collagen in the body, found alongside Type I in skin, blood vessels, and internal organs. Almost always consumed as part of a Type I and III bovine collagen blend. Supports skin firmness, vascular integrity, and gut lining health. Less independently studied than Type I but shares a robust combined evidence base.
StatusOTC Supplement
FormsOral · Powder
View Full Intel →
Skin & HairHuman RCT
Collagen Type I structure
Collagen Type I
Col-I
82
Collagen Type I
Col-I
Human RCT
The most abundant protein in the human body and the best-studied peptide supplement in this catalog. Derived from bovine or marine sources and hydrolyzed for absorption. Strong human RCT evidence for skin elasticity, joint comfort, nail strength, and bone density support. Widely available OTC as a powder, capsule, or liquid with an excellent safety profile.
StatusOTC Supplement
FormsOral · Powder
View Full Intel →
Recovery & PerformanceAnimal / In Vitro
KPV structure
KPV
Lys-Pro-Val
42
KPV
Lys-Pro-Val
Animal / In Vitro
A synthetic tripeptide derived from the C-terminal fragment of alpha-melanocyte stimulating hormone (α-MSH). Unlike most peptides in this catalog which stimulate or build, KPV is primarily a regulator — it quiets overactive inflammatory responses without broadly suppressing immune function. Most studied for gut inflammation, wound healing, and antimicrobial activity. One of the four components of the KLOW recovery stack.
StatusResearch Compound
FormsInjectable · Oral
View Full Intel →
Recovery & PerformanceAnimal Only
BPC-157 structure
BPC-157
Wolverine
20
BPC-157
Wolverine
Animal Only
A synthetic peptide studied in animal models for tendon repair, gut healing, and anti-inflammatory effects. Derived from a protein found in gastric juice. Shows remarkable healing properties across tendons, gut lining, and nervous system in animal studies. No human RCT data currently available. Widely used in the research community. Sold as a research compound only.
StatusResearch Compound
FormsInjectable · Oral
View Full Intel →
MetabolicHuman RCT
Tesamorelin structure
Tesamorelin
Egrifta
88
Tesamorelin
Egrifta
Human RCT
A synthetic analog of Growth Hormone Releasing Hormone (GHRH) and the only GHRH analog with an FDA-approved indication, making it one of the most clinically validated peptides in this catalog. Approved under the brand name Egrifta for the reduction of excess visceral abdominal fat in HIV patients with lipodystrophy. Widely used off-label in longevity and metabolic health contexts for its targeted visceral fat reduction and emerging cognitive benefits. Requires a prescription through a licensed provider.
StatusPrescription — FDA Approved
FormsInjectable
View Full Intel →

Everything you need to make an informed decision.

Mechanism of Action

Understand exactly how each peptide works at a biological level — written in plain English, not jargon.

Evidence Quality Rating

Every profile is graded by the strength of its research — Human RCT, Animal Only, or In Vitro. No ambiguity.

Risks & Contradictions

Side effects, drug interactions, and safety considerations are listed on every profile — not buried or omitted.

Evidence grades on every profile

Every peptide is rated Human RCT, Animal Only, or In Vitro, so you always know exactly what the science shows — not what a brand wants you to believe.

Risks alongside benefits

We include contradictions, side effects, and safety considerations on every profile. No cherry-picking. No incomplete pictures.

Zero sponsorships. Ever.

No brand pays to be featured on PeptideClear. Every profile is editorially independent and built on primary literature.

Questions & Answers

To learn more about PeptideClear feel free to contact us at hello@peptideclear.com

What is PeptideClear?

How do you grade evidence quality?

Are these peptides FDA approved?

How do you select which peptides to cover?

Is the information here medical advice?

How do I access peptides covered on this site?

When will new peptide profiles be added?

Stay ahead of the peptide curve.

Join our newsletter for new peptide profiles, research updates, and regulatory news.